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2018

Hoffmann T, Krug D, Bozkurt N, Duddela S, Jansen R, Garcia R, Gerth K, Steinmetz H, Müller R – Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria, Nat. Commun. 2018

DOI: 10.1038/s41467-018-03184-1


2017

Tesmar A, Hoffmann M, Pippel J, Fayad A, Dausend-Werner S, Bauer A, Blankenfeldt W, Müller R – Total biosynthesis of the pyrrolo[4,2]benzodiazepine scaffold tomaymycin on an In Vitro reconstituted NRPS system, Cell chemical biology 2017, 247, 1-12

DOI: 10.1016/j.chembiol.2017.08.001

Hüttel S, Testolin G, Herrmann J, Planke T, Gille F, Moreno M, Stadler M, Brönstrup M, Kirschning A, Müller R – Discovery and total synthesis of natural cystobactamid derivatives with superior activity against Gram-negative pathogens, Angew. Chem. Int. Ed. 2017

Pubmed: 28730677  
DOI: 10.1002/anie.201705913

Trauner D, Cheng B, Müller R – Total syntheses of cystobactamids and structural confirmation of cystobactamid 919-2, Angew. Chem. Int. Ed. 2017, 56, 7407-7410

Pubmed: 28731542  
DOI: 10.1002/anie.201705387

Kjaerulff L, Raju R, Panter F, Scheid U, Garcia R, Herrmann J, Müller R – Pyxipyrrolones: Structure elucidation and biosynthesis of cytotoxic myxobacterial metabolites, Angew. Chem. Int. Ed. 2017, 56, 9614-9618

Pubmed: 28590072  
DOI: 10.1002/anie.201704790

Fu C, Sikandar A, Donner J, Zaburannyi N, Herrmann J, Reck M, Wagner-Döbler I, Koehnke J, Müller R – Carolacton is a potent myxobacterial inhibitor of folate biosynthesis via specific interaction with FolD/MTHFD, Nature communications 2017, 8

Rox K, Rohde M, Chhatwal G, Müller R – Disorazoles block group A streptococcal invasion into epithelial cells via interference with the host factor ezrin, Cell Chem. Biol. 2017, 24, 159-170

DOI: 10.1016/j.chembiol.2016.12.011

Viehrig K, Surup F, Volz C, Herrmann J, Abou Fayad A, Adam S, Kohnke J, Trauner D, Müller R – Structure and biosynthesis of crocagins: polycyclic postranslationally modified ribosomal peptides from Chondromyces crocatus, Angew. Chem. Int. Ed. 2017

Pubmed: 28544148  
DOI: 10.1002/anie.201612640

Bock T, Volz C, Hering V, Scrima A, Müller R, Blankenfeldt W – The AibR-isovaleryl coenzyme A regulator and its DNA binding site - a model for the regulation of alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus, Nucleic Acids Res. 2017, 45, 2166-2178

Pubmed: 27940564  
DOI: 10.1093/nar/gkw1238

Fu C, Auerbach D, Li Y, Scheid U, Luxenburger E, Garcia R, Irschik H, Müller R – Solving the puzzle of the one-carbon loss in ripostatin biosynthesis, Angew. Chem. Int. Ed. 2017, 56, 2192-2197

DOI: 10.1002/anie.201609950


2016

Steinmetz H, Li J, Fu C, Zaburannyi N, Kunze B, Harmrolfs K, Schmitt V, Herrmann J, Reichenbach H, Hofle G, Kalesse M, Müller R – Isolation, structure elucidation, and (bio)synthesis of Haprolid, a cell-type-specific myxobacterial cytotoxin, Angew. Chem. Int. Ed. 2016, 55, 10113-7

Pubmed: 27404448  
DOI: 10.1002/anie.201603288

Wang H, Li Z, Jia R, Hou Y, Yin J, Bian X, Li A, Muller R, Stewart A, Fu J, Zhang Y – RecET direct cloning and Redab recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression, Nat. Protoc. 2016, 11, 1175-1190

Pubmed: 27254463  
DOI: 10.1038/nprot.2016.054

Zaburannyi N, Bunk B, Maier J, Overmann J, Müller R – Genome analysis of the fruiting body forming myxobacterium Chondromyces crocatus reveals high potential for natural product Biosynthesis, Appl. Environ. Microbiol. 2016, 82, 1945-57

Pubmed: 26773087  
DOI: 10.1128/AEM.03011-15

Lee W, Schaefer K, Qiao Y, Srisuknimit V, Steinmetz H, Müller R, Kahne D, Walker S – The mechanism of action of lysobactin, J. Am. Chem. Soc. 2016, 138, 100-103

Pubmed: 26683668  
DOI: 10.1021/jacs.5b11807

Gemperlein K, Zipf G, Bernauer H, Müller R, Wenzel S – Metabolic engineering of Pseudomonas putida for production of docosahexaenoic acid based on a myxobacterial PUFA synthase , Metab. Eng. 2016, 33, 98-108

Pubmed: 26617065  
DOI: 10.1016/j.ymben.2015.11.001


2015

Wenzel S, Hoffmann H, Zhang J, Debussche L, Haag-Richter S, Kurz M, Nardi F, Lukat P, Kochems I, Tietgen H, Schummer D, Nicolas J, Calvet L, Czepczor V, Vrignaud P, Mühlenweg A, Pelzer S, Müller R, Brönstrup M – Production of the bengamide class of marine natural products in myxobacteria: biosynthesis and structure-activity relationships, Angew. Chem. Int. Ed. 2015, 54, 15560-4

Pubmed: 26514647  
DOI: 10.1002/anie.201508277

Mohr K, Volz C, Jansen R, Wray V, Hoffmann J, Bernecker S, Wink J, Gerth K, Stadler M, Müller R – Pinensins: the first antifungal lantibiotics, Angew. Chem. Int. Ed. 2015, 127, 11254-11258

Pubmed: 26211520  
DOI: 10.1002/anie.201500927

Keller L, Plaza A, Dubiella C, Groll M, Kaiser M, Muller R – Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome, J. Am. Chem. Soc. 2015, 137, 8121-30

Pubmed: 26050527  
DOI: 10.1021/jacs.5b03833

Fu C, Keller L, Bauer A, Brönstrup M, Froidbise A, Hammann P, Herrmann J, Mondesert G, Kurz M, Schiell M, Schummer D, Toti L, Wink J, Müller R – Biosynthetic studies of telomycin reveal new lipopeptides with enhanced activity, J. Am. Chem. Soc. 2015, 137, 7692-7705

Pubmed: 26043159  
DOI: 10.1021/jacs.5b01794

Kling A, Lukat P, Almeida D, Bauer A, Fontaine E, Sordello S, Zaburannyi N, Herrmann J, Wenzel S, König C, Ammerman N, Barrio M, Borchers K, Bordon-Pallier F, Brönstrup M, Courtemanche G, Gerlitz M, Geslin M, Hammann P, Heinz D, Hoffmann H, Klieber S, Kohlmann M, Kurz M, Lair C, Matter H, Nuermberger E, Tyagi S, Fraisse L, Grosset J, Lagrange S, Müller R – Targeting DnaN for tuberculosis therapy using novel griselimycins, Science 2015, 348, 1106-1112

Pubmed: 26045430  
DOI: 10.1126/science.aaa4690

Sucipto H, Sahner J, Prusov E, Wenzel S, Hartmann R, Koehnke J, Müller R – In Vitro reconstitution of α-Pyrone ring formation in myxopyronin biosynthesis, Chem. Sci. 2015, 6, 5076-5085

DOI: 10.1039/C5SC01013F

Bian X, Plaza A, Zhang Y, Müller R – Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety, Chem. Sci. 2015, 6, 3154-3160

DOI: 10.1039/c5sc00101c


2014

Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro C, Bähre H, Tschirner S, Gorinski N, Gohmert M, Mayer C, Huehn J, Ponimaskin E, Abraham W, Müller R, Lochner M, Sparwasser T – De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells, Nat. Med. 2014, 20, 1327-1333

Pubmed: 25282359  
DOI: 10.1038/nm.3704

Baumann S, Herrmann J, Raju R, Steinmetz H, Mohr K, Hüttel S, Harmrolfs K, Stadler M, Müller R – Cystobactamids: myxobacterial topoisomerase inhibitors exhibiting potent antibacterial activity, Angew. Chem. Int. Ed. 2014, 53, 14605-14609

Pubmed: 25510965  
DOI: 10.1002/anie.201409964

Hoffmann T, Krug D, Hüttel S, Müller R – Improving natural products identification through targeted LC-MS/MS in an untargeted secondary metabolomics workflow, Anal. Chem. 2014, 86, 10780-10788

Pubmed: 25280058  
DOI: 10.1021/ac502805w

Reker D, Perna A, Rodrigues T, Schneider P, Reutlinger M, Mönch B, Koeberle A, Lamers C, Gabler M, Steinmetz H, Müller R, Schubert-Zsilavecz M, Werz O, Schneider G – Revealing the macromolecular targets of complex natural products, Nat. Chem. 2014, 6, 1072-1078

Pubmed: 25411885  
DOI: 10.1038/nchem.2095

Surup F, Viehrig K, Mohr K, Herrmann J, Jansen R, Müller R – Disciformycins A and B: 12-membered macrolide glycoside antibiotics from the myxobacterium Pyxidicoccus fallax active against multiresistant staphylococci , Angew. Chem. Int. Ed. 2014, 49, 13588-13591

Pubmed: 25294799  
DOI: 10.1002/anie.201406973

Müller S, Rachid S, Hoffmann T, Surup F, Volz C, Zaburannyi N, Müller R – Biosynthesis of crocacin involves an unusual hydrolytic release domain showing similarity to condensation domains, Chem. Biol. 2014, 21, 855-865

Pubmed: 24981773  
DOI: 10.1016/j.chembiol.2014.05.012

Etzbach L, Plaza A, Garcia R, Baumann S, Müller R – Cystomanamides: structure and biosynthetic pathway of a family of glycosylated lipopeptides from myxobacteria, Org. Lett. 2014, 16, 2414-2417

Pubmed: 24735013  
DOI: 10.1021/ol500779s

Gemperlein K, Rachid S, Garcia R, Wenzel S, Müller R – Polyunsaturated fatty acid biosynthesis in myxobacteria, Chem. Sci. 2014, 5, 1733-1741

DOI: 10.1039/C3SC53163E

Kolinko I, Lohße A, Borg S, Raschdorf R, Jogler C, Tu Q, Pósfai M, Tompa E, Plitzko J, Brachmann A, Wanner G, Müller R, Zhang Y, Schüler D – Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene clusters, Nat. Nanotechnol. 2014, 9, 193-197

Pubmed: 24561353  
DOI: 10.1038/nnano.2014.13


2013

Hoffmann T, Müller S, Nadmid S, Garcia R, Müller R – Microsclerodermins from terrestrial myxobacteria: An intriguing biosynthesis likely connected to a sponge symbiont, J. Am. Chem. Soc. 2013, 45, 16904-16911

Pubmed: 24124771  
DOI: 10.1021/ja4054509

Viehrig K, Surup F, Harmrolfs K, Jansen R, Kunze B, Müller R – Concerted action of P450 plus helper protein to form the amino-hydroxy-piperidone moiety of the potent protease inhibitor crocapeptin, J. Am. Chem. Soc. 2013, 135, 16885-16894

Pubmed: 24171398  
DOI: 10.1021/ja4047153


2012

Jahns C, Hoffmann T, Müller S, Gerth K, Washausen P, Höfle G, Reichenbach H, Kalesse M, Müller R – Pellasoren: structure elucidation, biosynthesis, and total synthesis of a cytotoxic secondary metabolite from Sorangium cellulosum, Angew. Chem. Int. Ed. 2012, 51, 5239-5243

Pubmed: 22488911  
DOI: 10.1002/anie.201200327

Fu J, Bian X, Hu S, Wang H, Huang F, Seibert P, Plaza A, Xia L, Müller R, Stewart A, Zhang Y – Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting, Nat. Biotechnol. 2012, 30, 440-446

Pubmed: 22544021  
DOI: 10.1038/nbt.2183

Li Y, Luxenburger E, Müller R – An alternative isovaleryl CoA biosynthetic pathway involving a previously unknown 3-methylglutaconyl CoA decarboxylase, Angew. Chem. Int. Ed. 2012, 52, 1304-1308

Pubmed: 23225771  
DOI: 10.1002/anie.201207984

Volz C, Kegler C, Müller R – Enhancer binding proteins act as hetero-oligomers and link secondary metabolite production to myxococcal development, motility and predation, Chem. Biol. 2012, 19, 1447-1459

Pubmed: 23177199  
DOI: 10.1016/j.chembiol.2012.09.010

Huo L, Rachid S, Stadler M, Wenzel S, Müller R – Synthetic biotechnology to study and engineer ribosomal bottromycin biosynthesis, Chem. Biol. 2012, 19, 1278-1287

Pubmed: 23021914  
DOI: 10.1016/j.chembiol.2012.08.013

Katsuyama Y, Harmrolfs K, Pistorius D, Li Y, Müller R – A semipinacol rearrangement directed by an enzymatic system featuring dual-function FAD-dependent monooxygenase, Angew. Chem. Int. Ed. 2012, 51, 9437-9440

Pubmed: 22907798  
DOI: 10.1002/anie.201204138

Barbier J, Jansen R, Irschik H, Benson S, Gerth K, Böhlendorf B, Höfle G, Reichenbach H, Wegner J, Zeilinger C, Kirschning A, Müller R – Isolation and total synthesis of icumazoles and noricumazoles--antifungal antibiotics and cation-channel blockers from Sorangium cellulosum, Angew. Chem. Int. Ed. 2012, 51, 1256-1260

Pubmed: 22213143  
DOI: 10.1002/anie.201106435

Cortina N, Krug D, Plaza A, Revermann O, Müller R – Myxoprincomide: a natural product from Myxococcus xanthus discovered by comprehensive analysis of the secondary metabolome, Angew. Chem. Int. Ed. 2012, 51, 811-816

Pubmed: 22162209  
DOI: 10.1002/anie.201106305

Quade N, Huo L, Rachid S, Heinz D, Müller R – Unusual carbon fixation gives rise to diverse polyketide extender units, Nat. Chem. Biol. 2012, 8, 117-124

Pubmed: 22138621  
DOI: 10.1038/nchembio.734


2011

Pistorius D, Li Y, Mann S, Müller R – Unprecedented anthranilate priming involving two enzymes of the acyl adenylating superfamily in aurachin biosynthesis, J. Am. Chem. Soc. 2011, 133, 12362-12365

Pubmed: 21770425  
DOI: 10.1021/ja203653w

Dehn R, Katsuyama Y, Weber A, Gerth K, Jansen R, Steinmetz H, Höfle G, Müller R, Kirschning A – Molecular basis of elansolid biosynthesis: evidence for an unprecedented quinone methide initiated intramolecular Diels-Alder cycloaddition/macrolactonization, Angew. Chem. Int. Ed. 2011, 50, 3882-3887

Pubmed: 21472917  
DOI: 10.1002/anie.201006880

Steinmetz H, Gerth K, Jansen R, Schläger N, Dehn R, Reinecke S, Kirschning A, Müller R – Elansolid A, a unique macrolide antibiotic from Chitinophaga sancti isolated as two stable atropisomers, Angew. Chem. Int. Ed. 2011, 50, 532-536

Pubmed: 21154488  
DOI: 10.1002/anie.201005226


2010

Binz T, Maffioli S, Sosio M, Donadio S, Müller R – Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster, J. Biol. Chem. 2010, 285, 32710-32719

Pubmed: 20710026  
DOI: 10.1074/jbc.M110.146803

Buntin K, Irschik H, Weissman K, Luxenburger E, Blöcker H, Müller R – Biosynthesis of thuggacins in myxobacteria: comparative cluster analysis reveals basis for natural product structural diversity, Chem. Biol. 2010, 17, 342-356

Pubmed: 20416506  
DOI: 10.1016/j.chembiol.2010.02.013

Chai Y, Pistorius D, Ullrich A, Weissman K, Kazmaier U, Müller R – Discovery of 23 natural tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004, Chem. Biol. 2010, 17, 296-309

Pubmed: 20338521  
DOI: 10.1016/j.chembiol.2010.01.016

Rachid S, Revermann O, Dauth C, Müller R – Characterization of a novel type of oxidative decarboxylase involved in the biosynthesis of the styryl moiety of chondrochloren from an acylated tyrosine, J. Biol. Chem. 2010, 285, 12482-12489

Pubmed: 20080978  
DOI: 10.1074/jbc.M109.079707


2009

Wenzel S, Müller R – The impact of genomics on the exploitation of the myxobacterial secondary metabolome, Nat. Prod. Rep. 2009, 26, 1385-1407

Pubmed: 19844638  
DOI: 10.1039/b817073h

Rachid S, Scharfe M, Blöcker H, Weissman K, Müller R – Unusual chemistry in the biosynthesis of the antibiotic chondrochlorens, Chem. Biol. 2009, 16, 70-81

Pubmed: 19171307  
DOI: 10.1016/j.chembiol.2008.11.005


2008

Menche D, Arikan F, Perlova O, Horstmann N, Ahlbrecht W, Wenzel S, Jansen R, Irschik H, Müller R – Stereochemical determination and complex biosynthetic assembly of etnangien, a highly potent RNA polymerase inhibitor from the myxobacterium Sorangium cellulosum , J. Am. Chem. Soc. 2008, 130, 14234-14243

Pubmed: 18826315  
DOI: 10.1021/ja804194c

Meiser P, Weissman K, Bode H, Krug D, Dickschat J, Sandmann A, Müller R – DKxanthene biosynthesis - understanding the basis for diversity-oriented synthesis in myxobacterial secondary metabolism, Chem. Biol. 2008, 15, 771-781

Pubmed: 18721748  
DOI: 10.1016/j.chembiol.2008.06.005

Perez J, Castaneda-Garcia A, Jenke-Kodama H, Müller R, Munoz-Dorado J – Eukaryotic-like protein kinases in the prokaryotes and the myxobacterial kinome, Proc. Natl. Acad. Sci. USA 2008, 105, 15950-15955

Pubmed: 18836084  
DOI: 10.1073/pnas.0806851105

Li Y, Weissman K, Müller R – Myxochelin biosynthesis: direct evidence for two- and four-electron reduction of a carrier protein-bound thioester, J. Am. Chem. Soc. 2008, 130, 7554-7555

Pubmed: 18498160  
DOI: 10.1021/ja8025278

Buntin K, Rachid S, Scharfe M, Blöcker H, Weissman K, Müller R – Production of the antifungal isochromanone ajudazols A and B in Chondromyces crocatus Cm c5: biosynthetic machinery and cytochrome P450 modifications , Angew. Chem. Int. Ed. 2008, 47, 4595-4599

Pubmed: 18461592  
DOI: 10.1002/anie.200705569


2007

Rachid S, Krug D, Weissman K, Muller R – Biosynthesis of (R)-beta-tyrosine and its incorporation into the highly cytotoxic chondramides produced by Chondromyces crocatus, The Journal of biological chemistry 2007, 282, 21810-21817

Pubmed: 17545150  
DOI: 10.1074/jbc.M703439200

Wenzel S, Müller R – Myxobacterial natural product assembly lines: fascinating examples of curious biochemistry, Nat. Prod. Rep. 2007, 24, 1211-1224

Pubmed: 18033576  
DOI: 10.1039/b706416k

Rachid S, Gerth K, Kochems I, Müller R – Deciphering regulatory mechanisms for secondary metabolite production in the myxobacterium Sorangium cellulosum So ce56 , Mol. Microbiol. 2007, 63, 1783-1796

Pubmed: 17367395  
DOI: 10.1111/j.1365-2958.2007.05627.x

Sandmann A, Dickschat J, Jenke-Kodama H, Kunze B, Dittmann E, Müller R – A type II polyketide synthase from the gram-negative bacterium Stigmatella aurantiaca is involved in aurachin alkaloid biosynthesis , Angew. Chem. Int. Ed. 2007, 46, 2712-2716

Pubmed: 17335090  
DOI: 10.1002/anie.200603513


2006

Meiser P, Bode H, Müller R – The unique DKxanthene secondary metabolite family from the myxobacterium Myxococcus xanthus is required for developmental sporulation, Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 19128-19133

Pubmed: 17148609  
DOI: 10.1073/pnas.0606039103

Wenzel S, Williamson R, Grünanger C, Xu J, Gerth K, Martinez R, Moss S, Carroll B, Grond S, Unkefer C, Müller R, Floss H – On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" units into ansamitocin and soraphen A, J. Am. Chem. Soc. 2006, 128, 14325-14336

Pubmed: 17076505  
DOI: 10.1021/ja064408t

Wenzel S, Meiser P, Binz T, Mahmud T, Müller R – Nonribosomal Peptide Biosynthesis: Point Mutations and Module Skipping Lead to Chemical Diversity, Angew. Chem. Int. Ed. 2006, 45, 2296-2301

Pubmed: 16506259  
DOI: 10.1002/anie.200503737


2005

Bode H, Müller R – The impact of bacterial genomics on natural product research, Angew. Chem. Int. Ed. 2005, 44, 6828-6846

Pubmed: 16249991  
DOI: 10.1002/anie.200501080

Wenzel S, Gross F, Zhang Y, Fu J, Stewart F, Müller R – Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering, Chem. Biol. 2005, 12, 349-356

Pubmed: 15797219  
DOI: 10.1016/j.chembiol.2004.12.012

Bode H, Dickschat J, Kroppenstedt R, Schulz S, Müller R – Biosynthesis of iso-fatty acids in myxobacteria: iso-even fatty acids are derived from Ó-aoxidation of iso-odd fatty acids, J. Am. Chem. Soc. 2005, 127, 532-533

Pubmed: 15643871  
DOI: 10.1021/ja043570y


2004

Sandmann A, Sasse F, Müller R – Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity, Chem. Biol. 2004, 11, 1071-1079

Pubmed: 15324808  
DOI: 10.1016/j.chembiol.2004.05.014

Bode H, Wenzel S, Irschik H, Höfle G, Müller R – Unusual biosynthesis of leupyrrins in the myxobacterium Sorangium cellulosum , Angew. Chem. Int. Ed. 2004, 43, 4163-4167

Pubmed: 15307077  
DOI: 10.1002/anie.200454240


2003

Weinig S, Hecht H, Mahmud T, Müller R – Melithiazol biosynthesis: further insights into myxobacterial PKS/NRPS systems and evidence for a new subclass of methyl transferases, Chem. Biol. 2003, 10, 939-952

Pubmed: 14583260  
DOI: 10.1016/j.chembiol.2003.09.012

Weinig S, Mahmud T, Müller R – Markerless mutations in the myxothiazol biosynthetic gene cluster: A delicate megasynthetase with a superfluous nonribosomal peptide synthetase domain, Chem. Biol. 2003, 10, 953-960

Pubmed: 14583261  
DOI: 10.1016/j.chembiol.2003.09.013

Bode H, Zeggel B, Silakowski B, Wenzel S, Reichenbach H, Müller R – Steroid biosynthesis in prokaryotes: identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)-oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca, Mol. Microbiol. 2003, 47, 471-481

Pubmed: 12519197  
DOI: 10.1046/j.1365-2958.2003.03309.x


2002

Mahmud T, Bode H, Silakowski B, Kroppenstedt R, Xu M, Nordhoff S, Höfle G, Müller R – A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria, J. Biol. Chem. 2002, 277, 32768-74

Pubmed: 12084727  
DOI: 10.1074/jbc.M205222200

Gaitatzis N, Silakowski B, Kunze B, Nordsiek G, Blöcker H, Höfle G, Müller R – The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase, J. Biol. Chem. 2002, 277, 13082-13090

Pubmed: 11809757  
DOI: 10.1074/jbc.M111738200


2001

Gaitatzis N, Kunze B, Müller R – In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases, Proc. Natl. Acad. Sci. USA 2001, 98, 11136-11141

Pubmed: 11562468  
DOI: 10.1073/pnas.201167098

Silakowski B, Nordsiek G, Kunze B, Blöcker H, Müller R – Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15, Chem. Biol. 2001, 8, 59-69

Pubmed: 11182319  
DOI: 10.1016/S1074-5521(00)00056-9


1999

Silakowski B, Schairer H, Ehret H, Kunze B, Weinig S, Nordsiek G, Brandt P, Blöcker H, Höfle G, Beyer S, Müller R – New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1, J. Biol. Chem. 1999, 274, 37391-37399

Pubmed: 10601310  
DOI: 10.1074/jbc.274.52.37391

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